Vol. 17 No. 2 (2025): Jurnal Farmasi Indonesia

Articles

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  Pengetahuan Apoteker terkait Covid-19 selama Pandemi

  Chilmia Nurul Fatiha, Azmi Rahmadani, Naniek Widyaningrum

  178-185

  • PDF 178-185 (Bahasa Indonesia)

  Abstract: 187 | PDF 178-185 (Bahasa Indonesia): 258
  

  Abstract

  Pharmacists’ role during Covid-19 pandemic is important in order to prevent and reduce the transmission rate. Pharmacist need to have good level of knowledge to ensure the role. This study aims to determine the level of pharmacists’ knowledge regarding Covid-19 and related factors. This is an observational study with cross-sectional approach. A questionnaire regarding Covid-19 was distributed to webinar participants in December 2021. The questionnaire is consisted of demographic questions and 15 Covid-19 knowledge questions. A total of 333 pharmacists responded, consisting of 32.4% community pharmacists, 33.9% hospital pharmacists, 24.0% clinical pharmacists, and 9.6% public health center pharmacists. Pharmacists have good knowledge of the causative virus (92%), symptoms (95.3%), supporting examinations (90.2%), therapy (95.8%), and prevention of Covid-19 transmission (94.4%) . Pharmacists' knowledge that needs to be improved is regarding vaccine storage (69.4%) and antibiotic use (56.1%). Semarang City pharmacists have good knowledge about Covid-19. Pharmacist knowledge was related to workplace (p<0.001) and length of work (p<0.001).

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  A Validated RP-HPLC-PDA with Buffer-Free Gradient Elution for Simultaneous Plasma Analysis of Trimethoprim and Sulfamethoxazole

  Nicholas Edmund, Untung Gunawan, Dion Notario

  186-199

  • PDF 186-199

  Abstract: 0 | PDF 186-199: 0
  

  Abstract

  A simple, cost-effective, and validated reversed-phase high-performance liquid chromatography (RP-HPLC) method is crucial for accurately monitoring trimethoprim and sulfamethoxazole therapy. However, conventional HPLC methods often rely on buffered mobile phases and additives, which can lead to column blockage and shorten column lifespan. To address this issue, we developed and validated a reversed-phase HPLC method with a photodiode array (PDA) detector, using a buffer-free and additive-free mobile phase with gradient elution. Sample preparation was performed using organic solvent-based deproteinization to minimize matrix effects. Chromatographic separation was performed on a ZORBAX Eclipse Plus C18 column (250 × 4.6 mm, 5 µm) using a mobile phase of acetic acid (pH 2.3), methanol, and acetonitrile at a flow rate of 1 mL/min. Detection was carried out at 270 nm with a total run time of 17 minutes. The analytical method exhibited linearity, precision, and accuracy, with adequate sensitivity for the analytes of interest. Stability testing yielded favorable results under various storage conditions, including the autosampler, freeze-thaw cycles, and long-term storage. However, the trimethoprim stock solution was only stable for two days and must be freshly prepared. Full validation was conducted in accordance with FDA and ICH bioanalytical guidelines, confirming its suitability for clinical application.

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  Pengaruh Edukasi Melalui Leaflet Terhadap Kepatuhan Pasien Hipertensi di Puskesmas Leuwiliang

  Nhadira Nhestricia, Lusi Indriani, Eko Nugraha Sulistio

  200-208

  • PDF 200-208

  Abstract: 0 | PDF 200-208: 0
  

  Abstract

  Leaflet merupakan salah satu media yang dapat digunakan dalam edukasi untuk meningkatkan pemahaman dan kepatuhan pasien dalam minum obat terutama bagi pasien yang memiliki regimen terapi yang kompleks, seperti hipertensi. Penelitian yang dilakukan di Puskesmas Leuwiliang bertujuan untuk menganalisis pengaruh pemberian edukasi melalui media leaflet terhadap peningkatan kepatuhan minum obat pasien hipertensi. Penelitian ini menggunakan metode quasi-eksperimental dengan rancangan Pretest-Posttest Design. Sejumlah 47 responden yang memenuhi kriteria bersedia mengikuti penelitian, berusia lebih dari 18 tahun, dan yang menjalani kontrol perawatan rutin hipertensi selama 3 bulan terakhir diwawancara untuk diukur kepatuhannya dalam minum obat, kemudian diberikan edukasi melalui leaflet. Setelah 1 bulan kepatuhan responden dalam minum obat kembali diukur. Data yang diperoleh dianalisis menggunakan uji wilcoxon dan menunjukkan bahwa pemberian edukasi melalui leaflet memberikan pengaruh sangat nyata terhadap peningkatan kepatuhan minum obat (p<0,020). Terdapat hubungan yang signifikan antara tingkat kepatuhan dengan tekanan darah sesudah diberikan intervensi pemberian informasi menggunakan media leaflet (p<0,003). Terdapat hubungan yang signifikan antara tingkat kepatuhan dengan kontrol tekanan darah (p=0,000). Penelitian ini menunjukkan bahwa edukasi melalui media leaflet berpengaruh sangat nyata dalam meningkatkan kepatuhan minum obat pasien hipertensi di Puskesmas Leuwiliang.