Vol. 14 No. 2 (2022): Jurnal Farmasi Indonesia

View Vol. 14 No. 2 (2022): Jurnal Farmasi Indonesia

Barcode 07

JFI Online Volume 14 Nomor 2, Juli 2022

DOI: https://doi.org/10.35617/jfionline.v14i2
Published: 02-07-2022

Articles

  • Monitoring Kepatuhan Pengobatan Pasien Diabetes Melitus Tipe 2 dengan Media Adherence Pill Box Unit Daily Dose

    Gulita Indah Tresnowati, Ikhwan Yuda Kusuma, Sunarti Sunarti
    97-104
    Abstract: 361 | PDF 97-104 (Bahasa Indonesia): 772

    Abstract

    Abstract: Diabetes mellitus (DM) is a group of metabolic diseases characterized by hyperglycemia due to affronts secretion disorders, affront action, or both. The management and management of DM is part of pharmaceutical care to reduce the causes of patient non-compliance in taking medication, resulting in complications. One way to prevent non-compliance is to provide a tool like Adherence Pill Box Unit Everyday Measurements. This study aimed to determine the effect of adherence pill box unit daily dose media in improving treatment adherence of type 2 DM patients. This study used an experimental method with the type of one gather pre-post test plan. Information was analyzed using the Wilcoxon rank test from the MMAS-8 questionnaire regarding medication adherence and blood sugar levels before and after being given the adherence pill box unit daily dose. The results of this study indicate the MMAS score – 8 sig. 0.002 < 0.05. This study concludes that there is an effect of Adherence Pill Box Unit Daily Dose media in improving medication adherence in patients, which has an impact on decreasing blood glucose levels in type 2 DM patients.

  • Perbandingan Stabilitas Nanopartikel Erithropoietin dalam Asam Klorida dan Phospate Buffer Saline

    Nuryanti Nuryanti, Akmad Kharis Nugroho, Ronny Martien, Madarina Julia
    105-111
    Abstract: 381 | PDF 105-111 (Bahasa Indonesia): 454

    Abstract

    Abstract: The erythropoietin nanoparticle system is formed from the interaction of the positive charge of chitosan and the negative charge of pectin under acidic conditions, so the stability of the nanoparticle system in hydrochloric acid and phosphate buffer Salin (PBS) is critical parameter in the choice of permeation medium. This study aimed to compare the stability of the erythropoietin nanoparticle system in HCl pH 1.2 and PBS pH 7.4. This research is an experimental laboratory study that analyzes includes the analysis of erythropoietin released from the nanoparticle system dissolved in HCl pH 1.2 and PBS pH 7.4 using spectrophotometric methods. Erythropoietin levels were calculated as free from the nanoparticle system at 15, 30, 45, 60, 90, 120, 180, and 240 minutes. Erythropoietin levels released from the erythropoietin nanoparticle system at 15 minutes in HCl medium pH 1.2 lower at 33, 63%, compared to PBS medium at pH 7.4 with free erythropoietin content of 50.85%. However, after 240 minutes the concentration of free erythropoietin from the nanoparticle system was higher in the PBS medium at pH 7.4 (60.49%) than in HCl medium at pH 1.2 (57.85%). The results showed that the erythropoietin nanoparticle system was more stable in HCl medium pH 1.2 than in PBS pH 7.4.

  • Evaluasi Penyebab Cacat Lahir Berdasarkan Jenis Kelamin di Sumatra Selatan, Indonesia

    Michael Michael, Diana Laila Ramatillah, Dwi Yunisa Dinli, Valerie Kezia, Azzahrotul Qona'ah Ibnatus Sutardi
    112-116
    Abstract: 220 | PDF 112-116 (Bahasa Indonesia): 301

    Abstract

    Abstract: Birth defects are inherited physical or genetic conditions that cause health complications and significant developmental delays such as intellectual functioning and adaptive behavior. The purpose of this study was to look at the types of disability, disability categories and causes of disability in boys and girls. Cross-sectional is the method used in this study. The sampling technique used in this study was convenience sampling by distributing questionnaires to parents who were willing to become respondents at special schools in South Sumatra. The results of this study involved a total of 96 respondents with 53 male and 43 female. There was no significant difference in the type of disability (0.49) suffered by boys and girls, no correlation was found between the severity of disability (0.91) and gender and there was no significant difference in the causes of disability (0.35) between boys and girls. men and women. Intellectual disability (62.5%) and mild disability (54.2%) were the most common disabilities. The main cause of disability is a deficiency of folic acid and multivitamins during pregnancy, which is 49%.

  • Analisis Pengaruh Kualitas Layanan Informasi Swamedikasi Online Berbasis Whatsapp Bot Terhadap Kepuasan Masyarakat

    Esti Ambar Widyaningrum, Farah Eka Julia Yestari, Erni Anika Sari, Indah Srihartini
    117-129
    Abstract: 359 | PDF 117-129 (Bahasa Indonesia): 530

    Abstract

    Abstract: The innovation of online self-medication information services, one of which is based on WhatsApp Bot, is needed to make it easier for people to find self-medication information for the community. This innovation needs to be continuously developed so that it can provide adequate information services, can increase knowledge and provide satisfaction to users. The purpose of this study was to determine the level of community satisfaction with online self-medication services based on WhatsApp Bot and the effect of expectations on satisfaction using the RATER dimension (Reliability, Assurance, Tangible, Empathy, Responsiveness) in the community of Talun Village, Blitar Regency. The method used in this study is an analytical survey using a cross sectional design. Sampling was done by purposive sampling technique and obtained 264 respondents from the residents of Talun Village, Blitar Regency. Gap analysis was obtained at -0.10 with a level of satisfaction that was not satisfied with the services that had been provided with detailed attributes including: layout, absence of constraints, valid and reliable information, complete information, attention to user needs and the speed of customer service responding, needs to be improved to increase user satisfaction. Spearman rank correlation test obtained P value 0.05 and correlation coefficient value of 0.644. The community is not satisfied with this information service and there is an influence between the quality of information source services and satisfaction in the community of Talun Village, Blitar Regency with a positive correlation and strong correlation strength so it is necessary to develop this Whatsapp Bot-based self- medication information service.

  • Evaluasi Hasil Klinis Pada Tim Medis yang Mendapat Vaksinasi Booster di Rumah Sakit Bengkayang Kalimantan Barat

    Stefanus Lukas, Diana Laila Ramatillah, Yufri Aldi, Fatma Sri Wahyuni, Ida Paulina, Fransisca Gloria, Michael Michael
    130-135
    Abstract: 174 | PDF 130-135 (Bahasa Indonesia): 131

    Abstract

    Abstract: In reducing the risk of transmission to health workers, the Government has given the 3rd Booster Covid-19 Vaccination since August 2021. This study uses the Astra Zeneca Vaccine, Moderna Vaccine and Pfizer Vaccine. The purpose of this study was to evaluate the effectiveness of the 3rd Booster vaccine and the clinical outcomes of post-vaccination health workers at West Kalimantan Hospital. Research method Observational Cross-sectional Prospective by conducting questionnaires and interviewing health workers. Samples were taken by convenience sampling and statistical analysis of chis-square. The research instrument used a questionnaire distributed in the hospital. In the study, it was found that as many as 12.60% (14 out of 118 health workers) were infected with Covid-19. The habit that influenced the effectiveness of the 3rd booster vaccination was sunbathing (p <0.05). The low severity of health workers infected with Covid-19 after the 3rd booster vaccine can be seen from the place of treatment, namely 97% independent isolation, 60% without using antivirals and 77% without using antibiotics. The type of vitamin that is most widely used is vitamin C. Hence with this booster vaccination aims to prevent and reduce the severity of patients who contract Covid-19 after vaccination.

  • Optimasi Sodium Croscarmellose dan Pati Jagung Pregelatinasi dalam Orally Disintegrating Tablet Setirizin Dihidroklorida

    Eka Deddy Irawan, Lusia Oktora Ruma Kumala Sari, Nitta Cahyaningrum
    136-146
    Abstract: 325 | PDF 136-146 (Bahasa Indonesia): 768

    Abstract

    Abstract: Cetirizine dihydrochloride (Cetirizine diHCL) is an effective antihistamine to treat allergies. Cetirizin diHCL tablets are a dosage form that is commonly on the market. However, people who experience allergies will have symptoms of difficulty swallowing which make it difficult to take cetirizine diHCl tablets. Therefore, it is necessary to make cetirizine diHCl in the form of orally disintegrating tablets (ODT) which can dissolve in saliva in a few seconds without chewing tablets or drink water. The proportion of binder and super disintegran was used in ODT preparations must be taken into calculation because it will greatly affect the physical characteristics of the tablets. This study aims to optimize the super disintegran Croscarmelose Sodium and pregelatinasi corn starch binders using factorial design methods. The responses studied were flow rate, hardness, brittleness, wetting time, and disintegration time. The increased Croscarmelose Sodium factor reduces the flow rate and hardness, increases brittleness, and decreases wetting and disintegration times. The increased factor of pregelatinasi corn starch will increase the flow rate and hardness, reduce friability and increase wetting time and disintegration time. The optimum formula was obtained from the concentration of Croscarmelose Sodium 6.613 mg and pregelatinasi corn starch 20 mg which resulted in a flow rate response of 13.438 g/second, hardness 4.646 kg, friability 0.815%, wetting time 63.667 seconds, and disintegration time 18.641seconds.

  • Profil Penyimpanan Obat LASA (Look Alike Sound Alike) Pada Beberapa Apotek di Kota Medan

    Eva Sartika Dasopang; Adinda Utami, Fenny Hasanah, Desy Natalia Siahaan, Niken Septriani Harefa
    147-154
    Abstract: 907 | PDF 147-154 (Bahasa Indonesia): 7929

    Abstract

    Abstract: Drug production in the current era is quite rapid so that many drugs have similar names and pronunciation and almost the same packaging known as LASA (Look Alike Sound Alike). The number of LASA drugs on the market must be considered, especially their storage. Improper storage of LASA drugs can cause drug administration errors to patients Objective: to see how LASA drug storage and LASA drug items are in several pharmacies in Medan city. The research was conducted by direct observation at the sampled pharmacies using an observation form table through a check list system, then calculated the percentage of LASA storage standards based on pharmaceutical service standards in pharmacies. This study involved 14 pharmacies that were willing to be involved in this study from the many pharmacies in Medan city, data were taken from December 2021 to March 2022. This study shows that only 50% of the 14 pharmacies sampled have implemented LASA (Look Alike Sound Alike) drug storage, while the other 50% have not implemented the LASA (Look Alike Sound Alike) drug storage system in accordance with statutory regulations, namely Permenkes number 58 of 2014. The implementation of LASA drug storage according to Permenkes No. 58 of 2014 is still quite low in Medan city.

  • Hubungan Tingkat Pengetahuan Masyarakat Terhadap Kesediaan Diri Vaksinasi COVID-19 RW 01 Kecamatan Cineam

    Ani Anggriani; Entris Sutrisno, Puti Bela Saskia
    155-163
    Abstract: 142 | PDF 155-163 (Bahasa Indonesia): 164

    Abstract

    Abstract: The spread of the COVID-19 virus is rapidly expanding so that it becomes a big problem due to the increasing number of positive patient cases and cases of patients dying. Various efforts have been made, one of which is implementing a vaccination program with the aim of being able to work effectively by producing specific antibodies in the body so that it can reduce the incidence and break the chain of transmission. The attitude of the community towards their willingness to carry out the vaccination program still raises pros and cons. On November 4, 2021, it was recorded that Tasikmalaya Regency was ranked first as the region with the lowest vaccination rate in West Java. This study aims to analyze whether there is a significant relationship between the level of public knowledge on self- availability for the COVID-19 vaccine in the RW 01 area, Cineam District, Tasikmalaya Regency. This research is included in the type of quantitative research with analytical observational method with a cross sectional approach. Data were collected by distributing questionnaires and obtained a sample of 338 respondents. Data were analyzed using SPSS for frequency test and correlation test with Spearman Rank. The results obtained for the level of community knowledge of 88.9% and self-willingness of 67.8%, and the correlation test obtained is a significance value of 0.000 (0.000 <0.05) indicating a significant relationship between the level of knowledge and the presence of the community for implement a vaccination program.

  • Aktivitas Antidislipidemia Rebusan Daun Mangga Kultivar Manalagi (Mangifera indica L. Var. Manalagi)

    Agus Sulaeman, Elis Susilawati, Shelin Aolina
    164-171
    Abstract: 403 | PDF 164-171 (Bahasa Indonesia): 618

    Abstract

    Abstract: Dyslipidemia is characterized by changes in lipid levels in plasma, a common indicator that is prone to the risk of cardiovascular disease. Plants that are suspected to have antidislipidemia activity, one of which is mango leaves. This study aimed to determine the effective dose in a decoction of mango manalagi leaves (Mangifera indica L. var. Manalagi) in decreasing levels of total cholesterol, triglycerides, LDL, and increasing HDL levels in high-fat feed-induced rats and propylthiouracil for 28 days. This research method was carried out preventively using 30 Wistar strain male rats which were grouped into 6 groups, namely negative control, positive control, comparison control (simvastatin 1.8mg/Kg BW), and a decoction test of manalagi mango leaves at a dose of 200, 400, 800 mg/kg BW. The parameters of the observed lipid profile are determined enzymatically using the micro lab. The results of the study on total cholesterol levels, showed the largest decreasing in the 200mg/kg BW dose group by 31.29%, in triglyceride levels the largest decreasing was found in the 400mg/kg BW dose group by 40.59%, in LDL levels the largest decreasing was found in the 200 mg/kg BW dose group by 48.03%, and in HDL levels there was the largest increasing in dose 800mg /kg BW of 97.40%. This study concludes that manalagi mango leaf decoction can be an antidyslipidemia in decreasing total cholesterol, triglyceride, and LDL levels as well as increasing HDL levels, with an effective dose of 200mg/ kg BW.

  • Formulasi Granul Sarang Walet Putih (Aerodramus fuciphagus) dengan Variasi Kombinasi Maltodextrin dan Povidon

    Ni Made Dharma Shantini Suena, Ketut Agus Adrianta, I Gusti Agung Ayu Kusuma Wardani, Ni Putu Udayana Antari
    172-189
    Abstract: 395 | PDF 172-189 (Bahasa Indonesia): 761

    Abstract

    Abstract: White swallow nest (SWP) contains Epidermal Growth Factor, which can increase immunity, and glutathione, which functions as an antioxidant. SWP has a high potential to become an antioxidant-rich immunomodulatory drink. Combining maltodextrin and povidone in a granule formula can protect the active substance from heat and maintain the flavor components. However, the wrong concentration can reduce the quality of the resulting granules. This study aims to obtain a combination of maltodextrin and povidone concentrations in SWP granule formulations that produce granules with the best quality and physical stability. The wet granulation method prepared the ten SWP formulas with combined concentrations of maltodextrin-povidone (code: F1 to F10). Evaluation of the physical quality of the granules (organoleptic, pH, soluble time, moisture content, compressibility index, and flow properties) was evaluated on the first, seventh, fourteenth, and twenty-first days. Linear regression is used to create an equation model of the effect of formulation on granule quality parameters. Formula F6 has the lowest compressibility index and the highest flow rate. There was no significant difference for all physical quality parameters of all formulas during storage (p>0.05). The effect of varying concentrations of maltodextrin is inversely proportional to the effect of varying concentrations of povidone on the physical quality of SWP granules. From the research results, it can be concluded that the combination of maltodextrin (5%) and povidone (1%) in F6 produces granules with the best physical quality. All formulas are stable during storage.

  • Artikel Review: Kandungan Senyawa Aktif Tanaman Untuk Kesehatan Kulit

    Neni Gunarti, Nia Yuniarsih, Rifqi Maulana Toni. S, Rita Khoerunnisa, Allahuddin Allahuddin, Fera Anggraeni, Tita Ruhdiana
    190-195
    Abstract: 863 | PDF 190-195 (Bahasa Indonesia): 2788

    Abstract

    Abstract: Background: Skin is the outermost organ of the body that coats the human body that needs to be treated to prevent skin damage from free radicals or infection. The way to maintain and care for the skin is using synthetic compounds that can help maintain healthy skin. Another alternative in skin care is to use plants that have active compounds that are beneficial for skin health and have relatively low side effects compared to synthetic chemicals. Objective: This study aimed to determine the active compounds of plants that can improve skin health. Method: Article review using Google Schoolar database with keywords related to the research topic, namely "Active Compounds, Plants, Health, Skin". Journals used in the last 10 years (2012-2022). Results: The results of a literature review show that there are 10 plants that can improve skin health, namely yam (Pachyrhizus erosus), liquorice (Glycyrrhiza glabra), arceola cherry (Malpighia emarginata), aloe vera (Aloe vera), guava (Psidium guajava L.), tomato (Solanum lycopersicum L.), Moringa leaf (Moringa oleifera), papaya (Carica papaya L), avocado (Persea americana M.) and sweet orange (Citrus x aurantium L) The active compounds in these plants that are beneficial for skin health are alkaloids, terpenoids, phenolics, flavonoids, carotenoids, polyphenols, tannins, steroids, triterpenoids, vitamin-C, vitamin-B, niacinamide, lycopene, glabridin, saponins and antraquinones. Conclusion: Active plant compounds that are beneficial for skin health are alkaloids, terpenoids, phenolics, flavonoids, carotenoids, polyphenols, tannins, steroids, triterpenoids, vitamin-C, vitamin-B, niacinamide, lycopene,  glabridin, saponins and antraquinones.

  • Variasi Konsentrasi Maltodekstrin Terhadap Karakteristik Fisik dan Aktivitas Antibakteri Orally Disintegrating Film Ekstrak Daun Pecut Kuda (Stachytarpheta jamaicencis L.)

    Yola Desnera Putri, Ledianasari Ledianasari, Farradiba Nur Aziza
    196-206
    Abstract: 320 | PDF 196-206 (Bahasa Indonesia): 615

    Abstract

    Abstract: Orally dissolving film (ODF) preparations are a new invention that allows drugs to be used more conveniently than other oral solid preparations without the need for drinking water. Porterweed (Stachytarpheta jamaicencis L) is one of herbal medicine that can be developed into an Orally Disintegrating Film (ODF) preparation with providing fast disintegration time and convenience comsumption especially for patients who have difficulty swallowing tablets. Main component in ODF preparations is polymer. Combination of HPMC K100M and maltodextrin produce good physical characteristics. The research was aimed to determine the influence of variations concentration 3.5 grams, 4.5 grams and 5.5 grams of maltodextrin on the physical characteristic of ODF containing porterweed extract. Stages of research carried out the formulation of basis and preparations continued with physical evaluated and antibacterical activity. To ensure that the resulting ODF preparations are ideal, evaluation tests need to be carried out including organoleptic, pH of the preparations, average weight, thickness, swelling index, disintegration time, tensile strength, percent elongation, and antibacterial activity. The best physical characterictis evaluation is formula 2 of ODF porterweed extract (Stachytarpheta jamaicencis L) containing 4.5 grams of maltodextrin with pH surface 6.75 ± 0.025, average weight 0.0499 ± 0.0001 g, thickness 0.0997 ± 0.002 mm,  swelling index in 15;30; and 45 sec. are 257.49 ± 0.244%; 322.46 ± 0.202%; and 403.21 ± 0.197%, disintegration time in 54 sec., tensile strength 12.67± 0.374 MPa, percent elongation 20% and have strong category of antibacterial ability against Staphylococcus aureus in 11.43 ± 1.401 mm.