Potensi Ekstrak Etanol Rimpang Kunyit Hitam (Curcuma caesia) dalam Melindungi Fungsi dan Struktur Ginjal Tikus yang Diinduksi Parasetamol Dosis Toksik

Abstract

Excessive use or overdose of paracetamol can result in increased reactive metabolites that can disrupt the integrity of cell membranes and lead to kidney damage. This study aims to determine the effect of black turmeric (Curcuma caesia) rhizome extract in preventing functional impairment and structural damage to the kidneys caused by paracetamol toxicity. This research was conducted experimentally using 20 rats which were divided into a negative control group which was only treated with a placebo, and treatment groups that were given black turmeric rhizome extract at a dose of 100 mg/kg, 200 mg/kg and 300 mg/kg, and a positive control group that was treated with curcuma tablets at a dose of 127.82 mg/Kg. Based on measurements of serum urea and creatinine levels of black turmeric rhizome extract at all doses were able to prevent an increase in kidney biomarkers, where the test results between groups were p <0.05, histopathological results at a dose of 200 mg/kg showed very minimal kidney damage compared to the placebo group . It was concluded that giving black turmeric ethanol extract, especially at a dose of 200 mg/kg-BW, has the potential to prevent damage to kidney tissue structure and function induced by toxic doses of paracetamol compared to the 100 mg/Kg and 300 mg/Kg extract groups which had greater damage to the kidney structure.